Liver fluke in cattle and sheep represents an increasing economic problem, particularly because of developing resistance to available drugs, as well as representing a serious animal welfare issue. This project will develop a nature based alternative treatment by using a bulk chemical that can be isolated in large quantities from a common non-food plant which is currently little used in the UK and often controlled by burning.The plant material, which itself is know to be actve against fluke, will be converted into a single chemical entity by simple processes and then modified to optimise its activity.
This will be determined using a highly specialised approach measuring in vitro many individual effects on the fluke, and during small in vivo studies. The consortium will develop and cost a complete product dossier, including material supply, product formulation, efficacy and delivery systems, a route to market,and an analysis of the potential benefits in controlling disease; it is expected that this project portfolio will either lead to a consortium partner moving directly to the process of full product registration , or to the consortium licencing the outputs so that such a process could begin.
The consortium consists of four companies, Naturiol, Bimeda Telsol, Ridgeway, and Phytoquest, and two Universitites, Aberystwyth and Bangor.
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